Available for the first time in over 100 years, welcome to 2900 Germantown Ave. - a rare opportunity to own a true piece of Philadelphia history. Positioned on the prominent corner of Germantown and Cambria Streets, this 4,350 sq. ft. mixed-use (CMX2) property has anchored the Germantown Ave. Business District for generations. Formerly home to the beloved Cambria Pharmacy for more than 96 years, this iconic location has long been a neighborhood staple and is now ready for its next chapter. The ground-level commercial space offers over 1,500 sq. ft. with access to a full unfinished basement, providing endless possibilities for retail, office, restaurant, studio, or creative business use. Inside, original cherry wood shelving still lines the walls, preserving the charm and craftsmanship of a bygone era while creating a warm and memorable atmosphere. Whether you're an investor, entrepreneur, or developer, this space is a blank canvas with incredible character and visibility. A separate private entrance on Cambria Street leads to two residential apartments located on the second and third floors. The second-floor unit features 3 bedrooms and 1 bathroom, while the third-floor unit offers 4 bedrooms and 1 bathroom. Both apartments boast 10+ foot ceilings, original architectural details, generous layouts, and abundant natural light, offering strong rental potential or owner-occupant flexibility. Located in Philadelphia's Fairhill neighborhood, the property sits within a growing corridor filled with history, culture, and ongoing investment. Germantown Avenue remains one of North Philadelphia's most active commercial thoroughfares, offering strong foot traffic, public transportation access, and excellent visibility for businesses. With its unique combination of commercial opportunity, residential income potential, and historic charm, 2900 Germantown Ave. is a one-of-a-kind property ready to make a lasting impression.